ChemicalBook CAS DataBase List 2-Bromo-4-chlorobenzaldehyde

2-Bromo-4-chlorobenzaldehyde synthesis

9synthesis methods

Product Name:2-Bromo-4-chlorobenzaldehyde
CAS Number:84459-33-6
Molecular formula:C7H4BrClO
Molecular Weight:219.46

143888-84-0
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$150.00/1g

84459-33-6
186 suppliers
$7.00/5g

Yield:84459-33-6 85%

Reaction Conditions:

with pyridinium chlorochromate in dichloromethane; for 2 h;

Steps:

83

Add pyridinium chlorochromate (432 mg, 2 mmol) to a solution of 2-bromo-4- chlorobenzyl alcohol (200 mg, 0.9 mmol) in dichloromethane (4 mL). Stir the resulting mixture for 2 h. Add diethyl ether (4 mL) and stir for 20 ^"min. Decant the diethyl ether solution. Wash the remaining solids with diethyl ether twice. Combine the diethyl ether solutions and concentrate. Chromatograph on silica gel, eluting with 20:80 to 1:1 ethyl acetate:dichloromethane to give 2-bromo-4-chlorobenzaldehyde as a white solid (167 mg, 85%).

References:

WO2006/44454,2006,A1 Location in patent:Page/Page column 47