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2-BROMO-5-CHLORO-3-FLUORO-4-IODOPYRIDINE synthesis

3synthesis methods
514797-97-8 Synthesis
2-Bromo-5-chloro-3-fluoropyridine

514797-97-8
124 suppliers
$4.00/1g

2-BROMO-5-CHLORO-3-FLUORO-4-IODOPYRIDINE

514798-05-1
11 suppliers
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Yield:514798-05-1 76%

Reaction Conditions:

Stage #1: 2-bromo-5-chloro-3-fluoro-pyridinewith n-butyllithium;diisopropylamine in tetrahydrofuran;hexane at -75; for 2 h;
Stage #2: with iodine in tetrahydrofuran;hexane at -75; for 1 h;

References:

Schlosser, Manfred;Bobbio, Carla [European Journal of Organic Chemistry,2002,# 24,p. 4174 - 4180]