ChemicalBook CAS DataBase List 2-Bromo-5-methoxybenzamide, 98

2-Bromo-5-methoxybenzamide, 98 synthesis

3synthesis methods

Product Name:2-Bromo-5-methoxybenzamide, 98
CAS Number:99848-43-8
Molecular formula:C8H8BrNO2
Molecular Weight:230.06

22921-68-2 Synthesis

22921-68-2
273 suppliers
$6.00/5g

99848-43-8
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$45.00/5mg

Yield:99848-43-8 93%

Reaction Conditions:

Stage #1: 2-bromo-5-methoxy-benzoic acidwith thionyl chloride at 60; for 6 h;
Stage #2: with ammonium hydroxide at 0 - 20;

Steps:

1.1 General procedure for preparing 2

General procedure: A mixture of corresponding o-bromobenzoic acids and SOCl₂ was stirred at 60 °C for 6 h. The mixture was subsequently evaporated and then it was added dropwise to the NH₄OH at an ice bath. After dropping, the reaction mixture was stirred at room temperature overnight. The mixture was filtered and the residue was dried under vacuum to afford the title compounds. 2-bromo-4-fluorobenzamide (2a) White solid; yield 89%;

References:

Chen, Weixiong;Feng, Bo;Han, Sheng;Wang, Peipei;Chen, Wuhong;Zang, Yi;Li, Jia;Hu, Youhong [Bioorganic and Medicinal Chemistry Letters,2022,vol. 58,art. no. 128526] Location in patent:supporting information

5813-86-5
95 suppliers
$30.00/5g

99848-43-8
18 suppliers
$45.00/5mg

References

56658-04-9
39 suppliers
$310.00/50g

99848-43-8
18 suppliers
$45.00/5mg

References