2-Bromo-5-methyl-3-(trifluoromethyl)pyridine synthesis

Yield:65996-08-9 59%

Reaction Conditions:

with HF;SF₄

Steps:

1.c METHOD A - Preparation of 2-Bromo-3-trifluoromethyl-5-methylpyridine

The 2-bromo-5-methylnicotinic acid (5.0 g, 0.023 m), SF₄ (31 g; 0.020 m) and HF (5.3 ml) were charged to a steel bomb. The contents were heated at 120° for 8 hours. After cooling to room temperature, the bomb was opened and the contents poured into saturated Na₂ CO₃ solution and extracted with CHCl₃ (3*100 ml). The organic layer was dried over Na₂ SO₄, filtered and concentrated to dryness. The residue distilled at 45°-49° (0.1 mm) to yield 4 g (59% yield) of 2-bromo-3-trifluoromethyl-5-methylpyridine.

References:

US4279913,1981,A