![](/CAS/20180629/GIF/65996-08-9.gif)
2-Bromo-5-methyl-3-(trifluoromethyl)pyridine synthesis
- Product Name:2-Bromo-5-methyl-3-(trifluoromethyl)pyridine
- CAS Number:65996-08-9
- Molecular formula:C7H5BrF3N
- Molecular Weight:240.02
![3-Pyridinecarboxylic acid, 2-broMo-5-Methyl-](/CAS/GIF/65996-06-7.gif)
65996-06-7
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![2-Bromo-5-methyl-3-(trifluoromethyl)pyridine](/CAS/20180629/GIF/65996-08-9.gif)
65996-08-9
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Yield:65996-08-9 59%
Reaction Conditions:
with HF;SF4
Steps:
1.c METHOD A - Preparation of 2-Bromo-3-trifluoromethyl-5-methylpyridine
The 2-bromo-5-methylnicotinic acid (5.0 g, 0.023 m), SF4 (31 g; 0.020 m) and HF (5.3 ml) were charged to a steel bomb. The contents were heated at 120° for 8 hours. After cooling to room temperature, the bomb was opened and the contents poured into saturated Na2 CO3 solution and extracted with CHCl3 (3*100 ml). The organic layer was dried over Na2 SO4, filtered and concentrated to dryness. The residue distilled at 45°-49° (0.1 mm) to yield 4 g (59% yield) of 2-bromo-3-trifluoromethyl-5-methylpyridine.
References:
US4279913,1981,A