ChemicalBook CAS DataBase List 2-BROMO-6-CHLORO-4-NITROANILINE

2-BROMO-6-CHLORO-4-NITROANILINE synthesis

9synthesis methods

Product Name:2-BROMO-6-CHLORO-4-NITROANILINE
CAS Number:99-29-6
Molecular formula:C6H4BrClN2O2
Molecular Weight:251.47

121-87-9 Synthesis

121-87-9
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99-29-6
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$8.00/10g

Yield: 97.62%

Reaction Conditions:

with sodium chlorate;sulfuric acid;hydrogen bromide in water at 35 - 65;

Steps:

1.d; 2.d; 3.d; 1.d; 2.d; 3.d; 4.d; 5-10
(d) Bromination reaction: add 60g sulfuric acid and 240g water to 450g of brominated waste acid to prepare bottom acid, add 90g of o-chloro-p-nitroaniline prepared in step (c) to bottom acid and add hydrobromic acid 44.2g, prepare 19.5g of sodium chlorate as a solution, slowly drop in, dropwise addition temperature 35 , drop to warm up to 65 heat preservation reaction to the end, suction filtration and washing to obtain 2-chloro-4-nitro-6- Bromo-aniline 127.7g, purity 99.1%.

References:

Zhejiang Runtu Institute Co., Ltd.;Gu Gaowei;Chen Baoxing;Gao Lijiang;Huang Zhong CN111039798, 2020, A Location in patent:Paragraph 0040; 0044; 0046; 0050-0051; 0055-0056; 0060-0061