2-bromo-9-hexyl-9H-carbazole synthesis
- Product Name:2-bromo-9-hexyl-9H-carbazole
- CAS Number:864550-95-8
- Molecular formula:C18H20BrN
- Molecular Weight:330.26
3652-90-2
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111-25-1
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864550-95-8
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Yield:864550-95-8 94%
Reaction Conditions:
Stage #1: 2-bromo-9H-carbazolewith tetrabutylammomium bromide;sodium hydroxide at 20; for 0.0833333 h;
Stage #2: 1-bromo-hexane for 12 h;
Steps:
1.I (I) Synthesis of alkyl chain carbazole group
To a 250 mL three-necked flask, 2-bromocarbazole (6.0 g, 24.38 mmol), sodium hydroxide solution (50%) 4 ml, tetrabutylammonium bromide (0.4 g, 1.24 mmol), and the temperature was stirred for 5 min at room temperature. Bromine hexane (8.045 g, 48 mmol) was added dropwise with a syringe.After 12 h of reaction, the eluent was purified by column chromatography to petroleum ether to afford product 1a as an oil, which, after vacuum drying, weighed 7.57 g (yield about 94%).
References:
CN108424424,2018,A Location in patent:Paragraph 0040; 0042; 0043
3460-18-2
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864550-95-8
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70873-41-5
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864550-95-8
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98-80-6
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864550-95-8
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