2-BROMO-N-(3,4-DIMETHYL-PHENYL)-ACETAMIDE synthesis
- Product Name:2-BROMO-N-(3,4-DIMETHYL-PHENYL)-ACETAMIDE
- CAS Number:349120-87-2
- Molecular formula:C10H12BrNO
- Molecular Weight:242.11
Yield: 97%
Reaction Conditions:
with diisopropyl-carbodiimide in tetrahydrofuran for 2 h;
Steps:
4
Preparative Example 4: Synthesis of 2-bromo-N-(3,4-dimethylphenvO acetamide; 0.2 g (1.65 mmol) of 3,4-dimethylaniline compound was dissolved in 5 ml of tetrahydrofuran, to which 0.45 g(3.30 mmol) of bromo acetic acid and 0.51 ml(3.30 mmol) of 1,3-diisopropylcarbodiimide were added. The resulting mixture was stirred for 2 hours under a nitrogen atmosphere, the solvent was removed under a reduced pressure, and the residue was shaken with a mixture of ethyl acetate and brine. The organic phase was separated, dried over anhydrous sodium sulfate, filtered, and distilled under a reduced pressure, to obtain a crude product. The crude product was purified by column chromatography(hexane:ethylacetate=4:l) to obtain 0.38 g of the title compound(yield: 97%) .1H NMR(300MHz, DMSOd6): δ 2.17(s, 3H), 2.19(s, 3H), 4.00(s, 2H), 7.06(d, IH), 7.30(d, IH), 7.34(s, IH), 10.20(s, IH); MS(m/e, M4): 243, 241, 121, 106.
References:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY WO2008/69611, 2008, A1 Location in patent:Page/Page column 17
95-64-7
228 suppliers
$5.00/5 g
598-21-0
306 suppliers
$10.00/10 g
349120-87-2
14 suppliers
$46.00/1 g
22118-09-8
172 suppliers
$21.21/10gm:
95-64-7
228 suppliers
$5.00/5 g
349120-87-2
14 suppliers
$46.00/1 g