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ChemicalBook CAS DataBase List 2-Bromo-N-methylbenzenesulphonamide
98192-14-4

2-Bromo-N-methylbenzenesulphonamide synthesis

7synthesis methods
-

Yield:98192-14-4 99%

Reaction Conditions:

in ethanol; for 2 h;Reflux;

Steps:

2-Bromo-N-methylbenzenesulfonamide (20a); Typical Procedure

General procedure: To a solution of commercially available 2-bromobenzenesulfonyl chloride (18, 500 mg, 1.96 mmol) in EtOH (20 mL), MeNH2 (0.7 mL,7.83 mmol) was added and the mixture was refluxed for 2 h. The residual solvent was evaporated under reduced pressure and the crude product obtained was purified by column chromatography (10% EtOAc-PE) to afford 20a12 (484 mg, 99%) as a white solid; mp 99-101 °C; Rf = 0.20 (10% EtOAc-PE).

References:

Debnath, Sudarshan;Mondal, Shovan [Synthesis,2016,vol. 48,# 5,p. 710 - 722]

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