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593266-85-4

2-Bromoacetyl-7-ethylbenzofuran synthesis

3synthesis methods
59664-03-8 Synthesis
2-Acetyl-7-ethylbenzofuran

59664-03-8
13 suppliers
$85.00/500mg

2-Bromoacetyl-7-ethylbenzofuran

593266-85-4
11 suppliers
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Yield:593266-85-4 85%

Reaction Conditions:

with acetic acid;pyridinium hydrobromide perbromide at 35 - 50; for 2 h;

Steps:

Synthesis of 2-bromo-1-(7-ethylbenzofuran-2-yl)ethanone 4

Into a solution of 3 (16 g, 0.1 mol) in acetic acid (100 mL) pyridinium tribromide (28.7 g, 0.9 equiv.) was added in small portions at35 °C. The reaction was completed at 50 °C (controlled by TLC with dichloromethane as eluent, approx. 2 h). The reaction mixture was poured on ice-cooled water; the precipitate formed was filtered and redissolved in dichloromethane. The organic solution was dried over Na2SO4, the solvent was further removed in vacuo, and the crude product was purified by column chromatography using n-hexane-dichloromethane 1:4 (v/v) as eluent.

References:

Nagy, Botond;Dima, Norbert;Paizs, Csaba;Brem, Jürgen;Irimie, Florin Dan;Toa, Monica Ioana [Tetrahedron Asymmetry,2014,vol. 25,# 18-19,p. 1316 - 1322]