2-(BROMOACETYL)PYRIDINE HYDROBROMIDE synthesis
- Product Name:2-(BROMOACETYL)PYRIDINE HYDROBROMIDE
- CAS Number:17570-98-8
- Molecular formula:C7H7Br2NO
- Molecular Weight:280.94
1122-62-9
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17570-98-8
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Yield:17570-98-8 97.8%
Reaction Conditions:
with hydrogen bromide;bromine;glacial acetic acid at 15 - 75; for 2 h;
Steps:
1.1.3 (3) 2-Bromo-acetylpyridineHydrobromide (C)synthesis:
At 15 , the bromine (1.52mL, 9.72mmol) was slowly added dropwise to 2-acetyl-pyridine (3g, 2.78mmol) in 30% HBr / HOAc (12mL), and after completion of the dropwise addition, the reaction solution at 40 under stirring 1h, then stirred at 75 1h. The reaction solution was cooled to 20 , to which was added Et2O (30mL), and stirred at this temperature for 30min, the resulting yellow precipitate was filtered, and the precipitate was washed with 10mL diethyl ether, and dried to (6.81g, 97.8%).
References:
CN105524056,2016,A Location in patent:Paragraph 0048; 0049; 0050
1122-54-9
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17570-98-8
143 suppliers
$6.00/250mg
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17570-98-8
143 suppliers
$6.00/250mg