2-(BroMoMethyl)-5-fluoro-1,3-diMethylbenzene synthesis
- Product Name:2-(BroMoMethyl)-5-fluoro-1,3-diMethylbenzene
- CAS Number:200799-19-5
- Molecular formula:C9H10BrF
- Molecular Weight:217.08
50-00-0
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461-97-2
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200799-19-5
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Yield:200799-19-5 34%
Reaction Conditions:
with hydrogen bromide in acetic acid at 20; for 4 h;
Steps:
67
A mixture of Scheme 60 compound 1 (5.0 g, 40.32 mmol), paraformaldehyde (15.0 g) and HBr (33% in acetic acid, 35 mL) in acetic acid (25 mL) was stirred at RT for 4 h. After TLC showed the starting material was completely consumed, the reaction mixture was diluted with water (30 mL) and extracted with petroleum ether (2 x 40 mL) then dried over Na2S04, filtered and concentrated under reduced pressure to give a residue which was purified by flash chromatography on silica gel (eluting with petroleum ether/EtOAc 100/0 gradually increasing to 90/10) to give Scheme 60 compound 2 (3.0 g, 34%) as an off-white solid. MS [ESI, MH+] = 217.99.
References:
WO2014/52365,2014,A1 Location in patent:Page/Page column 310
461-97-2
190 suppliers
$5.00/1g
200799-19-5
23 suppliers
$165.00/1g