2-carboxymethyl-5-trifluoromethyl-benzoic acid synthesis
- Product Name:2-carboxymethyl-5-trifluoromethyl-benzoic acid
- CAS Number:207804-91-9
- Molecular formula:C10H7F3O4
- Molecular Weight:248.16
1483-56-3
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Yield:207804-91-9 59%
Reaction Conditions:
Stage #1: 2-bromo-5-(trifluoromethyl)benzoic acid;ethyl acetoacetatewith sodium hydride;copper(I) bromide in mineral oil at 80; for 3.5 h;Sealed tube;Inert atmosphere;
Stage #2: with sodium hydroxide at 20; under 760.051 Torr; for 2 h;
References:
Trost, Barry M.;Kalnmals, Christopher A. [Chemistry - A European Journal,2018,vol. 24,# 36,p. 9066 - 9074] Location in patent:supporting information