2-chloro-1-(4-fluorophenyl)-2-phenylethanone synthesis
- Product Name:2-chloro-1-(4-fluorophenyl)-2-phenylethanone
- CAS Number:62148-67-8
- Molecular formula:C14H10ClFO
- Molecular Weight:248.68
Yield: 85%
Reaction Conditions:
with aluminum (III) chloride at 0 - 80; for 4 h;
Steps:
3
The synthetic method is described as follows:150 g of fluorobenzene and 33 g of aluminum trichloride were added to 500 ml of a three-necked flask, and 47 g of the compound (3) obtained in Example 2 was added dropwise to 0 ° C, and the dropping speed was 47 g / h. After the dropping was completed, To 80 ° C, the reaction was carried out for 4 hours, the reaction system was lowered to 0 ° C and poured into 100 mL of 2 mol / L hydrochloric acid at 0 ° C. Standing, stratified, take the organic solution layer, with saturated sodium bicarbonate to adjust the pH to neutral. The organic layer is taken into the organic layer, and the organic layer is obtained by mixing twice, and the organic layer is separated and concentrated to no longer have the liquid to be distilled off. The organic layer is separated from the organic layer, To give 2-chloro-1- (4-fluorophenyl) -acetophenone weighing 52 g and 85% yield.
References:
Nanjing Ocean Pharmaceutical Technology Co.,Ltd.;Chen, Bensun;Zhou, Changyue;Xu, Qiubin CN103420823, 2016, B Location in patent:Paragraph 0032; 0033
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