2-Chloro-3-ethoxypyridine synthesis

Yield:63756-58-1 99 %

Reaction Conditions:

with potassium carbonate

Steps:

P.3.1 Step 1:

Step 1:
2-chloro-3-ethoxypyridine
2-Chloropyridin-3-ol (10.0 g, 77 mmol), iodoethane (14.45 g, 93 mmol) and potassium carbonate (21.34 g, 154 mmol) were added to 77 mL of DMF and stirred at room temperature for 48 hours.
The reaction mixture was filtered and water was added, followed by extraction with ethyl acetate.
After washing with water and brine, the organic layer was dried over magnesium sulfate and concentrated under reduced pressure.
The desired product was obtained by purification with column chromatography. (Yield 99%)
¹H NMR (400 MHz, CHLOROFORM-D): δ 7.96 (t, J = 3.0 Hz, 1H), 7.17 (d, J = 3.2 Hz, 2H), 4.10 (q, J = 7.0 Hz, 2H), 1.48 (t, J = 7.1 Hz, 3H)

References:

EP4071147,2022,A1