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2-CHLORO-3-ETHYLQUINOLINE synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C
1.2: 4 h / 0 - 20 °C
2.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 12 h / 20 °C

References:

Das, Sandip Kumar;Roy, Satyajit;Khatua, Hillol;Chattopadhyay, Buddhadeb [Journal of the American Chemical Society,2020,vol. 142,# 38,p. 16211 - 16217]