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2-Chloro-3-isopropoxypyrazine synthesis
- Product Name:2-Chloro-3-isopropoxypyrazine
- CAS Number:1209457-92-0
- Molecular formula:C7H9ClN2O
- Molecular Weight:172.61
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4858-85-9
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Yield:-
Reaction Conditions:
at 20;
Steps:
A
To a solution of dihalide derivative (1eq.) in dry THF or dioxane or DMF was added amine (1-1.5 eq.) alone or alcohol (1-1.5 eq.) with NaH (1-5 eq.) at room temperature. After stirring for 17 hours at room temperature or 115° C., piperazine derivative (1-5 eq.) was added and the resulting mixture was heated up to 115° C. for 1 hour to 1 week. Then, the solvents were evaporated. The residue was partitioned between EtOAc and sat. NaHCO3. The aqueous layer was extracted with EtOAc. The organic layer was washed with water, dried over MgSO4 and concentrated to afford the crude product, which was purified by silica gel column chromatography or Shimadzu automated preparative HPLC System.
References:
US2007/249579,2007,A1 Location in patent:Page/Page column 19-20; 30