ChemicalBook CAS DataBase List 2-CHLORO-3-PHENYLPYRIDINE

2-CHLORO-3-PHENYLPYRIDINE synthesis

8synthesis methods

Product Name:2-CHLORO-3-PHENYLPYRIDINE
CAS Number:31557-57-0
Molecular formula:C11H8ClN
Molecular Weight:189.64

78607-36-0 Synthesis

78607-36-0
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$14.00/1g

98-80-6 Synthesis

98-80-6
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$5.00/5g

31557-57-0
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Yield:31557-57-0 99%

Reaction Conditions:

with potassium carbonate in ethanol;lithium hydroxide monohydrate at 80; under 1500.15 Torr; for 0.666667 h;Flow reactor;

Steps:

6 Example 6

The present embodiment provides a preparation method of 2-chloro-3-phenylpyridine based on a continuous flow reactor, comprising: Dissolve 10 mmol of 2-chloro-3-iodopyridine, 10 mmol of phenylboronic acid and 10 mmol of potassium carbonate in 80 ml of ethanol/water (3:1) mixed solution as a material solution. Then, the material was injected into the continuous flow reactor through a plunger pump, the temperature of the reactor was controlled at 80° C, the system pressure was controlled at 2 bar, and the residence time data was 40 min. After the product was collected, it was separated by column chromatography to obtain 1.88 g of 2-chloro-3-phenylpyridine with a yield of 99%, the content of palladium in the product detected by atomic absorption spectrometer was less than 1 ppm.

References:

CN113956231,2022,A Location in patent:Paragraph 0103-0106