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ChemicalBook CAS DataBase List 2-chloro-4-(2-naphthyl)pyrimidine

2-chloro-4-(2-naphthyl)pyrimidine synthesis

3synthesis methods
3934-20-1 Synthesis
2,4-Dichloropyrimidine

3934-20-1
709 suppliers
$9.00/1g

32316-92-0 Synthesis
2-Naphthaleneboronic acid

32316-92-0
463 suppliers
$6.00/1g

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Yield:488816-96-2 66%

Reaction Conditions:

with tetrakis-(triphenylphosphine)-palladium;Cs2CO3 in 1,4-dioxane;lithium hydroxide monohydrate at 70; for 20 h;Suzuki Coupling;

References:

Galal, Kareem A.;Truong, Anna;Kwarcinski, Frank;De Silva, Chandi;Avalani, Krisha;Havener, Tammy M.;Chirgwin, Michael E.;Merten, Eric;Ong, Han Wee;Willis, Caleb;Abdelwaly, Ahmad;Helal, Mohamed A.;Derbyshire, Emily R.;Zutshi, Reena;Drewry, David H. [Journal of Medicinal Chemistry,2022,vol. 65,# 19,p. 13172 - 13197]