ChemicalBook CAS DataBase List 2-Chloro-4-(4-methoxyphenyl)pyrimidine

2-Chloro-4-(4-methoxyphenyl)pyrimidine synthesis

5synthesis methods

Product Name:2-Chloro-4-(4-methoxyphenyl)pyrimidine
CAS Number:75634-04-7
Molecular formula:C11H9ClN2O
Molecular Weight:220.65

3934-20-1 Synthesis

3934-20-1
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$9.00/1g

5720-07-0 Synthesis

5720-07-0
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$6.00/5g

75634-04-7
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$256.00/500mg

Yield:75634-04-7 97%

Reaction Conditions:

with sodium carbonate;tetrakis(triphenylphosphine) palladium⁽⁰⁾ in water;acetonitrile at 90; for 16 h;

Steps:

5; 25.1

To a solution of 4-methoxyphenylboronic acid (3.0 g, 19.7 mmol) and 2,4- dichloropyrimidine (5.9 g, 39.0 mmol) in dry acetonitrile (120 mL) was added a 0.4 M solution of Na2CO3 (120 mL) followed by Pd (PPh3) 4 (400 mg, 0.35 mmol). The suspension was degassed and heated at 90°C for 16 h, cooled down and concentrated to produce a precipitate which was collected by filtration, washed with water, dried and purified by flash chromatography on silica gel (EtOAc/CH2CI2 : 5/95) to afford the title compound 17 (4.25 g, 19.3 mmol, 97% yield).

References:

WO2005/92899,2005,A1 Location in patent:Page/Page column 61

3934-20-1 Synthesis

3934-20-1
708 suppliers
$9.00/1g

104-92-7 Synthesis