2-CHLORO-4,6-DIMORPHOLIN-4-YL-1,3,5-TRIAZINE synthesis
- Product Name:2-CHLORO-4,6-DIMORPHOLIN-4-YL-1,3,5-TRIAZINE
- CAS Number:7597-22-0
- Molecular formula:C11H16ClN5O2
- Molecular Weight:285.73
110-91-8
676 suppliers
$9.00/1g
6601-22-5
114 suppliers
$5.00/250mg
7597-22-0
48 suppliers
$49.00/250mg
Yield: 82.3%
Reaction Conditions:
with potassium carbonate in tetrahydrofuran;ethanol at 20; for 12 h;
Steps:
9.2 Step 2: Synthesis of 4,4'-(6-chloro-1,3,5-triazine-2,4-diyl)bismorpholine
Synthetic method: 4-(2,6-dichloropyrimidin-4-yl)morpholine (5.0 g, 21.37 mmol) synthesized in Step 1 was dissolved in THF/EtOH (50 mL).Add morpholine (2.22 g, 25.46 mmol), potassium carbonate (4.42 g, 32.06 mmol), and react at room temperature for 12 h.After the reaction was completed by TLC, the solvent was evaporated under reduced pressure and EtOAc (50mL)It was washed once with H2O (50 mL) and saturated NaCl (50 mL) and dried over anhydrous Na2SO4.The solvent was evaporated under reduced pressure to give a crude product.Column chromatography purification (PE / EtOAc = 5 / 1)Obtained 5.01 g of an intermediate white solid.Yield: 82.3%;
References:
Guizhou Medical University;Zhang Jiquan;Li Shumin;Xu Xiaoqian;Wu Tingting;Tang Lei CN108191837, 2018, A Location in patent:Paragraph 0177; 0178
110-91-8
676 suppliers
$9.00/1g
108-77-0
395 suppliers
$13.00/25g
7597-22-0
48 suppliers
$49.00/250mg
110-91-8
676 suppliers
$9.00/1g
108-77-0
395 suppliers
$13.00/25g
6601-22-5
114 suppliers
$5.00/250mg
7597-22-0
48 suppliers
$49.00/250mg