2-Chloro-4-aMino-benzeneMethanol synthesis
- Product Name:2-Chloro-4-aMino-benzeneMethanol
- CAS Number:51420-25-8
- Molecular formula:C7H8ClNO
- Molecular Weight:157.6
46004-37-9
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$6.00/250mg
51420-25-8
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$174.16/1g
Yield:51420-25-8 95%
Reaction Conditions:
with lithium aluminium tetrahydride in tetrahydrofuran at 0 - 20; for 0.5 h;
Steps:
150
Weigh 4-amino-2-chlorobenzoic acid methyl ester (4.2g, 22.7mmol) in anhydrous tetrahydrofuran (100mL), add lithium aluminum tetrahydrogen (LiAlH4) (1g, 25mmol) in batches at 0°C,Naturally cool to room temperature and react for 0.5h,After the completion of the reaction was monitored by TLC, an appropriate amount of ether, water and 1N sodium hydroxide solution were added to the reaction solution, the mixture was suction filtered through Celite, and the organic solvent in the filtrate was removed under reduced pressure to obtain a yellow solid of compound C40 (3.387g, The yield is 95%).
References:
CN112608320,2021,A Location in patent:Paragraph 0905-0911
2457-76-3
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$5.00/1g
51420-25-8
26 suppliers
$174.16/1g
52301-88-9
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51420-25-8
26 suppliers
$174.16/1g