2-Chloro-4-(diMethylaMino)-6-Methylnicotinonitrile synthesis

2synthesis methods

Product Name:2-Chloro-4-(diMethylaMino)-6-Methylnicotinonitrile
CAS Number:137440-91-6
Molecular formula:C9H10ClN3
Molecular Weight:195.65

4-(dimethylamino)-6-methyl-2-oxo-1H-pyridine-3-carbonitrile

98694-78-1
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2-Chloro-4-(diMethylaMino)-6-Methylnicotinonitrile

137440-91-6
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Yield:137440-91-6 89.6%

Reaction Conditions:

with N,N-dimethyl-formamide;trichlorophosphate in toluene; for 6 h;Heating;

References:

Mezentseva, M. V.;Faermark, I. F.;Kuleshova, E. F.;Anisimova, O. S.;Shvarts, G. Ya.;et al. [Pharmaceutical Chemistry Journal,1991,vol. 25,# 9,p. 623 - 628][Khimiko-Farmatsevticheskii Zhurnal,1991,vol. 25,# 9,p. 29 - 33]