![](/CAS/GIF/58348-98-4.gif)
2-chloro-4-fluoro-6-nitrophenol synthesis
- Product Name:2-chloro-4-fluoro-6-nitrophenol
- CAS Number:58348-98-4
- Molecular formula:C6H3ClFNO3
- Molecular Weight:191.54
![2-Chloro-4-fluorophenol](/CAS/GIF/1996-41-4.gif)
1996-41-4
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![2-chloro-4-fluoro-6-nitrophenol](/CAS/GIF/58348-98-4.gif)
58348-98-4
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Yield:58348-98-4 83%
Reaction Conditions:
with nitric acid;acetic acid in water at 0; for 5 h;
Steps:
77.77(A)
Example 77; 7-Chloro-5-fluoro-2-(4-( pyridin-2- )but-3-ynyl)benzo[d]oxazole; 77(A) 2-Chloro-4-fluoro-6-nitrophenol; 2-Chloro-4-fluorophenol (5.64 g, 38.5 mmol) was added to a solution of acetic acid (16.5 mL), nitric acid (8.66 mL) and water (7.5 mL) at 0°C. The reaction mixture was stirred vigorously for 5 hours at 0°C. The resulting precipitate was filtered, washed with water and dried under vacuum to yield 2-chloro-4-fluoro-6-nitrophenol (6.12 g, 32.0 mmol, 83%) as a yellow powder.
References:
WO2005/123703,2005,A2 Location in patent:Page/Page column 133