2-CHLORO-4-FLUOROBENZYLAMINE synthesis

Yield:-

Reaction Conditions:

with ammonia in methanol at 50; for 2 h;Inert atmosphere;

Steps:

1 1-(2-Chloro-4-fluorophenyl)methanamine

To a stirred solution of 1-(bromomethyl)-2-chloro-4-fluorobenzene (1 g, 1 equiv.) in DMF (5 mL) was added NH3(g) in MeOH (5 mL) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 50 degrees celsius under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The reaction was monitored by LCMS. The resulting mixture was used in the next step(E00848-157) directly without further purification

References:

WO2019/55966,2019,A2 Location in patent:Page/Page column 433; 434