2-CHLORO-4-HYDROXY-BENZOIC ACID METHYL ESTER synthesis
- Product Name:2-CHLORO-4-HYDROXY-BENZOIC ACID METHYL ESTER
- CAS Number:104253-44-3
- Molecular formula:C8H7ClO3
- Molecular Weight:186.59
67-56-1
738 suppliers
$7.29/5ml-f
56363-84-9
171 suppliers
$14.14/250mgs:
104253-44-3
91 suppliers
$21.00/100mg
Yield: 100%
Reaction Conditions:
with thionyl chloride for 12 h;Reflux;
Steps:
SOCl2 (1.5 ml) was added to 2-chloro-4-hydroxy-benzoic acid (5 g, 0.03 mmol) in methanol (10 ml). The mixturewas slowly warmed from room temperature to reflux temperature and the reaction solution was refluxed for 12 hoursand concentrated under reduced pressure to give compound 132A (red solid, 5.4 g, the yield was 100%).1H NMR (400MHz, DMSO-d6) δ: 10.71 (s, 1H), 7.84 - 7.71 (m, 1H), 6.91 (d, J=2.4 Hz, 1H), 6.82 (dd, J=2.4, 8.7 Hz, 1H),3.79 (s, 3H).
References:
GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD;LONG, Chaofeng;CHEN, Zhengxia;CHEN, Xiaoxin;ZHANG, Yang;LIU, Zhuowei;LI, Peng;CHEN, Shuhui;LIANG, Guibai;XIE, Cheng;LI, Zhengwei;FU, Zhifei;HU, Guoping;LI, Jian EP3293177, 2018, A1 Location in patent:Paragraph 0332; 0333
2457-76-3
287 suppliers
$5.00/1g
104253-44-3
91 suppliers
$21.00/100mg
3336-16-1
106 suppliers
$13.00/250mg
104253-44-3
91 suppliers
$21.00/100mg