2-CHLORO-4'-HYDROXYCHALCONE synthesis
- Product Name:2-CHLORO-4'-HYDROXYCHALCONE
- CAS Number:5424-02-2
- Molecular formula:C15H11ClO2
- Molecular Weight:258.7
Yield:5424-02-2 92%
Reaction Conditions:
with sodium hydroxide in ethanol; for 12 h;Cooling with ice;
Steps:
1.1 Step 1, Preparation of 3-(2-chlorophenyl)-1-(4-hydroxyphenyl)-2-propen-1-one (Intermediate 1):
1.5g of p-hydroxyacetophenone (11.02mmol) and 1.86g of 2-chlorobenzaldehyde (13.22mmol) were added to a 100mL three-necked flask, then 25mL (30.05mmol) of ethanol was added to fully dissolve the reactant, and 35mL of 5% ethanol was added. NaOH (30.05 mmol) solution.Magnetic stirring, under ice bath conditions for 12 h until the reactants reacted completely, monitored by TLC until the raw material point disappeared, poured the reaction system in the three-necked flask into a 500 mL ice bath beaker, and added 5% HCl dropwise with a plastic tip dropper solution, until the pH value in the beaker is measured with pH test paper is about 6, a large amount of white solid is precipitated at the bottom of the beaker as intermediate 1, suction filtration, under the condition of 45 , dry in a far-infrared drying oven (TIR-X31 type ) 8h (8-48h can be used), standby, yield: 92%.
References:
CN114085199,2022,A Location in patent:Paragraph 0038; 0039; 0040
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5424-02-2
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