2-Chloro-4-isopropoxy-5-nitropyrimidine synthesis

Yield: 53%

Reaction Conditions:

with potassium carbonate at 40; for 16 h;

References:

Marsilje, Thomas H.;Pei, Wei;Chen, Bei;Lu, Wenshuo;Uno, Tetsuo;Jin, Yunho;Jiang, Tao;Kim, Sungjoon;Li, Nanxin;Warmuth, Markus;Sarkisova, Yelena;Sun, Frank;Steffy, Auzon;Pferdekamper, Annemarie C.;Li, Allen G.;Joseph, Sean B.;Kim, Young;Liu, Bo;Tuntland, Tove;Cui, Xiaoming;Gray, Nathanael S.;Steensma, Ruo;Wan, Yongqin;Jiang, Jiqing;Chopiuk, Greg;Li, Jie;Gordon, W. Perry;Richmond, Wendy;Johnson, Kevin;Chang, Jonathan;Groessl, Todd;He, You-Qun;Phimister, Andrew;Aycinena, Alex;Lee, Christian C.;Bursulaya, Badry;Karanewsky, Donald S.;Seidel, H. Martin;Harris, Jennifer L.;Michellys, Pierre-Yves [Journal of Medicinal Chemistry,2013,vol. 56,# 14,p. 5675 - 5690]