2-Chloro-4-methoxy-3-(trifluoromethyl)pyridine synthesis

5synthesis methods

Product Name:2-Chloro-4-methoxy-3-(trifluoromethyl)pyridine
CAS Number:1163693-02-4
Molecular formula:C7H5ClF3NO
Molecular Weight:211.57

626-03-9
340 suppliers
$5.00/1g

2-Chloro-4-methoxy-3-(trifluoromethyl)pyridine

1163693-02-4
20 suppliers
inquiry

Yield:-

Steps:

Multi-step reaction with 4 steps
1: iodine; potassium carbonate / water / 100 °C
2: trichlorophosphate / N,N-dimethyl-formamide / 90 °C
3: methanol / 20 - 45 °C
4: potassium fluoride; copper(l) iodide / 1-methyl-pyrrolidin-2-one / 1.5 h / 80 - 120 °C

References:

BOEHRINGER INGELHEIM INTERNATIONAL GmbH;STAMMERS, Timothy;BARBEAU, Xavier;BEAULIEU, Pierre;BERTRAND-LAPERLE, Megan;BROCHU, Christian;EDWARDS, Paul, J.;FORGIONE, Pasquale;GODBOUT, Cédrickx;HUCKE, Oliver;JOLY, Marc-André;LANDRY, Serge;LEPAGE, Olivier;NAUD, Julie;PESANT, Marc;POIRIER, Martin;POIRIER, Maude;THAVONEKHAM, Bounkham WO2011/32277, 2011, A1

1514-87-0 Synthesis