ChemicalBook CAS DataBase List 2-CHLORO-4-METHOXYQUINAZOLINE

2-CHLORO-4-METHOXYQUINAZOLINE synthesis

6synthesis methods

Product Name:2-CHLORO-4-METHOXYQUINAZOLINE
CAS Number:77767-98-7
Molecular formula:C9H7ClN2O
Molecular Weight:194.62

607-68-1 Synthesis

607-68-1
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124-41-4 Synthesis

124-41-4
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77767-98-7
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Yield:77767-98-7 96%

Reaction Conditions:

with methanol at 20; for 48 h;

Steps:

23.b

To a stirred solution of 2,4-dichloroquinazoline (Preparation 23a, 2.0 g, 10.0 mmol) in methanol (100 mL) was added a 5M solution of sodium methoxide in methanol (2.1 mL, 10.5 mmol) and the mixture was stirred at ambient temperature for 48 hours. The solvent was evaporated and the mixture was partitioned between ethyl acetate and water. The organic phase was dried (MgS0₄) and evaporated to give the title compound (1.87 g, 96%) as a solid.LRMS (m/z): 195 (M+1)+/-.H-NMR δ (CDCI₃): 4.23 (s, 3H), 7.57 (ddd, 1 H), 7.88 - 7.84 (m, 2H), 8.17 - 8.11(m, 1 H).

References:

WO2011/76419,2011,A1 Location in patent:Page/Page column 117-118

67-56-1 Synthesis