2-Chloro-4-phenyl-oxazole synthesis

Yield:445470-08-6 74%

Reaction Conditions:

Stage #1: 4-phenyl-1,3-oxazolewith lithium hexamethyldisilazane in tetrahydrofuran at -78;
Stage #2: with hexachloroethane in tetrahydrofuran at -78 - 20; for 16 h;

References:

Perner, Richard J.;Koenig, John R.;Didomenico, Stanley;Gomtsyan, Arthur;Schmidt, Robert G.;Lee, Chih-Hung;Hsu, Margaret C.;McDonald, Heath A.;Gauvin, Donna M.;Joshi, Shailen;Turner, Teresa M.;Reilly, Regina M.;Kym, Philip R.;Kort, Michael E. [Bioorganic and Medicinal Chemistry,2010,vol. 18,# 13,p. 4821 - 4829] Location in patent:supporting information; experimental part