2-Chloro-4-phenyl-thieno[2,3-d]pyrimidine synthesis

3synthesis methods

Product Name:2-Chloro-4-phenyl-thieno[2,3-d]pyrimidine
CAS Number:56844-18-9
Molecular formula:C12H7ClN2S
Molecular Weight:246.72

18740-39-1
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98-80-6 Synthesis

98-80-6
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2-Chloro-4-phenyl-thieno[2,3-d]pyrimidine

56844-18-9
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Yield:56844-18-9 60%

Reaction Conditions:

with tetrakis(triphenylphosphine) palladium⁽⁰⁾;potassium carbonate in ethanol;water;toluene at 110; for 4 h;Inert atmosphere;

Steps:

1.2 Synthesis of TP-1

Under a nitrogen stream 2,4-dichlorothieno [2,3-d] pyrimidine (4.2 g, 20.5 mmol), phenylboronic acid (2.5 g,Pd (PPh3) 4 (1.2 g, 5 mol%) and potassium carbonate (8.5 g, 61.5 mmol)Toluene / H 2 O / Ethanol (80 ml / 40 ml / 40 ml) was added thereto, and the mixture was stirred at 110 ° C for 4 hours.After completion of the reaction, the organic layer was separated using methylene chloride, and water was removed using MgSO4. Solvent in organic layerThe residue was purified by column chromatography to obtain the target compound TP-1 (3.0 g, 12.3 mmol, yield 60%).

References:

KR2015/36982,2015,A Location in patent:Paragraph 0099; 0104-0108

18740-38-0 Synthesis

18740-38-0
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56844-18-9
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References

Thieno[2,3-d]pyrimidin-2(1H)-one, 4-phenyl-

21582-50-3
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56844-18-9
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References