ChemicalBook CAS DataBase List 2-CHLORO-4-PHENYLQUINAZOLINE

2-CHLORO-4-PHENYLQUINAZOLINE synthesis

6synthesis methods

Product Name:2-CHLORO-4-PHENYLQUINAZOLINE
CAS Number:29874-83-7
Molecular formula:C14H9ClN2
Molecular Weight:240.69

A 2 L flask was charged with 35.0 g (175.8 mmol) of 2,4-dichloroquinoline,22.5 g (184.6 mmol) of phenylboronic acid, 6.1 g (5.3 mmol) of tetrakis(triphenylphosphine)palladium(0) were added to 800 mL of tetrahydrofuran and 400 mL of water, and the mixture was heated to 60 ° C for 12 hours under a nitrogen stream. . The resulting mixture was added to methanol (3000 mL), and the crystallized solid was filtered and dissolved in toluene, filtered through silica gel / celite, and the organic solvent was removed in an appropriate amount, and then recrystallization from methanol gave Intermediate I-A52-1 (36.8 g, 87% yield).

607-68-1 Synthesis

607-68-1
312 suppliers
$10.00/1g

98-80-6 Synthesis

98-80-6
712 suppliers
$5.00/5g

29874-83-7
187 suppliers
$10.00/1g

Yield:29874-83-7 87%

Reaction Conditions:

with tetrakis-(triphenylphosphine)-palladium;potassium carbonate in tetrahydrofuran;lithium hydroxide monohydrate at 60; for 12 h;Inert atmosphere;

Steps:

4 Synthesis of intermediate I-A52-1

A 2 L flask was charged with 35.0 g (175.8 mmol) of 2,4-dichloroquinoline,22.5 g (184.6 mmol) of phenylboronic acid, 6.1 g (5.3 mmol) of tetrakis(triphenylphosphine)palladium(0) were added to 800 mL of tetrahydrofuran and 400 mL of water, and the mixture was heated to 60 ° C for 12 hours under a nitrogen stream. . The resulting mixture was added to methanol (3000 mL), and the crystallized solid was filtered and dissolved in toluene, filtered through silica gel / celite, and the organic solvent was removed in an appropriate amount, and then recrystallization from methanol gave Intermediate I-A52-1 (36.8 g, 87% yield).

References:

KR2017/10582,2017,A Location in patent:Paragraph 0251-0254

6141-13-5 Synthesis