![](/CAS/GIF/53645-94-6.gif)
2-chloro-5-Methyl-1,3,4-thiadiazole synthesis
- Product Name:2-chloro-5-Methyl-1,3,4-thiadiazole
- CAS Number:53645-94-6
- Molecular formula:C3H3ClN2S
- Molecular Weight:134.59
![2-Amino-5-methyl-1,3,4-thiadiazole](/CAS/GIF/108-33-8.gif)
108-33-8
257 suppliers
$6.00/1g
![2-chloro-5-Methyl-1,3,4-thiadiazole](/CAS/GIF/53645-94-6.gif)
53645-94-6
29 suppliers
$45.00/25mg
Yield:53645-94-6 84%
Reaction Conditions:
with pyrylium tetrafluoroborate;magnesium chloride in acetonitrile; for 16 h;Heating;Sealed tube;
Steps:
General procedure for the chlorination of amino heteroaromatic compounds
General procedure: Unless otherwise specified, an 18 ml screw-capped tube under normal atmosphere is charged with pyrylium tetrafluoroborate 1 (1.5 equiv.) and MgCl2 (2.0 equiv.). The starting material (1.0 equiv.) is then added and directly followed by CH3CN (0.1 M). The resulting mixture is then stirred 5 minutes at 25 °C and then 16 hours at 120 °C. The reaction is allowed to cool to 25 °C. The crude mixture is partitioned between water and EtOAc. The aqueous layer is extracted with EtOAc (3 × 10 ml). The combined organic layers are dried over Na2SO4, concentrated to dryness and purified on silica gel to afford the desired product.
References:
Ghiazza, Clément;Faber, Teresa;Gómez-Palomino, Alejandro;Cornella, Josep [Nature Chemistry,2022,vol. 14,# 1,p. 78 - 84]
![5-methyl-3H-[1,3,4]thiadiazol-2-one](/CAS/GIF/84352-65-8.gif)
84352-65-8
23 suppliers
inquiry
![2-chloro-5-Methyl-1,3,4-thiadiazole](/CAS/GIF/53645-94-6.gif)
53645-94-6
29 suppliers
$45.00/25mg