{2-chloro-5-nitrophenyl}acetic acid synthesis
- Product Name:{2-chloro-5-nitrophenyl}acetic acid
- CAS Number:37777-70-1
- Molecular formula:C8H6ClNO4
- Molecular Weight:215.59
2444-36-2
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Yield:37777-70-1 80%
Reaction Conditions:
with sulfuric acid;nitric acid in water at -10 - 0;
Steps:
2
A solution of 2-(2-chlorophenyl)acetic acid (500 mmol) in conc. sulfuric acid (0.7 mL/mmol) was cooled to -10°C. A freshly prepared mixture of fuming nitric acid fuming (809 mmol) and conc. sulfuric acid (1.6 mol) was slowly added at -10°C. The mixture was allowed to warm to 0°C over 1h and was stirred for 4h at 0°C. The solution was slowly poured onto crushed ice/water (3 L). The mixture was stirred vigorously and the formed precipitate was isolated by filtration. The white solid residue was washed with an excess of water (4 L) and dried, giving 2-(2-chloro-5-nitrophenyl)acetic acid (80%).
References:
EP2112150,2009,A1 Location in patent:Page/Page column 28
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