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2-CHLORO-5-OXAZOLO[4,5-B]PYRIDIN-2-YL-PHENYLAMINE synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: polyphosphoric acid / 4 h / 220 °C
2: iron; hydrogenchloride / ethanol / Reflux

References:

Ferrins, Lori;Rahmani, Rapha?l;Sykes, Melissa L.;Jones, Amy J.;Avery, Vicky M.;Teston, Eliott;Almohaywi, Basmah;Yin, JieXiang;Smith, Jason;Hyland, Chris;White, Karen L.;Ryan, Eileen;Campbell, Michael;Charman, Susan A.;Kaiser, Marcel;Baell, Jonathan B. [European Journal of Medicinal Chemistry,2013,vol. 66,p. 450 - 465]