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2-chloro-5-(piperidin-1-ylcarbonyl)aniline synthesis

1synthesis methods
-

Yield:91766-96-0 45%

Reaction Conditions:

with N-(3-dimethylaminopropyl)-N-ethylcarbodiimide in N,N-dimethyl-formamide;acetonitrile at 20; for 16 h;

References:

Allison, Brett D.;Phuong, Victor K.;McAtee, Laura C.;Rosen, Mark;Morton, Magda;Prendergas, Clodagh;Barrett, Terry;Lagaud, Guy;Freedman, Jamie;Li, Na;Wu, Xiaodong;Venkatesan, Hariharan;Pippel, Marna;Woods, Craig;Rizzolio, Michèle C.;Hack, Michael;Hoey, Kenway;Deng, Xiaohu;King, Christopher;Shankley, Nigel P.;Rabinowitz, Michael H. [Journal of Medicinal Chemistry,2006,vol. 49,# 21,p. 6371 - 6390]