2-chloro-6,8-difluoroquinoline synthesis

Yield:577967-70-5 90%

Reaction Conditions:

with trichlorophosphate at 95 - 100; for 2 h;

Steps:

4.6. Preparation of 2-chloroquinolines (general procedure)

General procedure: A mixture of quinolin-2-one and POCl₃ was stirred at 95-100°C for 2 h and then cooled. Ice was added to the mixture. The precipitated material was filtered off,washed with water and dried.

References:

Skolyapova, Alexandrina D.;Selivanova, Galina A.;Tretyakov, Evgeny V.;Bogdanova, Tatjana F.;Shchegoleva, Lyudmila N.;Bagryanskaya, Irina Yu.;Gurskaya, Larisa Yu.;Shteingarts, Vitalij D. [Tetrahedron,2017,vol. 73,# 9,p. 1219 - 1229] Location in patent:supporting information