2-CHLORO-6-FLUOROQUINAZOLIN-4(3H)-ONE synthesis

Yield:769158-12-5 640 mg

Reaction Conditions:

with sodium hydroxide in tetrahydrofuran at 25; for 16 h;Inert atmosphere;

Steps:

b b) 2-Chloro-6-fluoro-3H-quinazolin-4-one

A mixture of IN NaOH (9.0 niL, 3.23 mmol), THF (9 niL), and 2,4-dichloro-6- fluoro-quinazoline (700.0 mg, 3.23 mmol) was stirred at RT under N₂ for 16 h at 25 °C . The solution was chilled and adjusted to pH 5 with AcOH. Then it was extracted with EtOAc and the obtained organic layer was washed with 0, dried over Na₂S0₄ and concentrated under reduced pressure to get an off-white solid (640 mg, 3.22 mmol). ^lH NMR (400 MHz, DMSO- ₆) δ 7.81 - 7.69 (m, 2H), 7.69 (dd, J= 8.9, 5.1 Hz, 1H). MS (EI): m/z = 197.4 [M-H]^".

References:

WO2019/72785,2019,A1 Location in patent:Page/Page column 211