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2-Chloro-6-Methoxy-4-Methylquinolin-8-aMine synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: 96 percent / xylene / Heating
2: 83 percent / m-chloroperbenzoic acid / CHCl3 / Ambient temperature
3: 78 percent / POCl3 / CHCl3 / Heating
4: 87 percent / N2H4*H2O / ethanol; H2O / Heating

References:

LaMontagne;Blumbergs;Smith [Journal of Medicinal Chemistry,1989,vol. 32,# 8,p. 1728 - 1732]