2-CHLORO-6-METHYLNICOTINAMIDE synthesis
- Product Name:2-CHLORO-6-METHYLNICOTINAMIDE
- CAS Number:54957-84-5
- Molecular formula:C7H7ClN2O
- Molecular Weight:170.6
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Yield:-
Reaction Conditions:
Stage #1: 2-chloro-6-methyl nicotinic acidwith oxalyl dichloride in dichloromethane at 20; for 2 h;
Stage #2: with ammonium hydroxide in tetrahydrofuran at 20; for 2 h;
Steps:
Intermediate 24 (1109) 2-chloro-6-methylnicotinamide
A mixture of (COCl)2 (3.8 mL, 44 mmol) and 2-chloro-6-methylnicotinic acid (5.0 g, 29 mmol) in DCM (30 mL) was stirred at 20°C for 2 hours. Then the mixture was concentrated under reduced pressure to give a residue that was treated with THF (30 mL) and NFL FLO (30 mL) at 20°C for 2 hours. The resulting mixture was filtered and the filtrate was concentrated under reduced pressure to give the title compound.
References:
WO2020/92667,2020,A1 Location in patent:Page/Page column 99; 100
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