2-CHLORO-7-METHOXYQUINAZOLIN-4(3H)-ONE synthesis

Yield:20197-98-2 63%

Reaction Conditions:

in tetrahydrofuran;

Steps:

1 Step 1

Step 1
2,4-dichloro-7-methoxyquinazoline (500 mg, 2.183 mmol) was suspended in 2% aqueous NaOH (6 mL). THF (1 mL) was added and the reaction was stirred for 4 h.
The reaction was diluted with water and the solid that remained was filtered off.
The aqueous phase was diluted with 1 N HCl.
The precipitate that formed was filtered, washed with water and dried to give 2-chloro-7-methoxyquinazolin-4-ol (288 mg, 63% yield). MS: MS m/z 211.1 (M⁺+1).

References:

US2013/115190,2013,A1 Location in patent:Page/Page column