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2-chloro-7-(trifluoroMethyl) quinoline synthesis

4synthesis methods
1011533-24-6 Synthesis
7-(Trifluoromethyl)quinolin-2-ol

1011533-24-6
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Yield:83183-56-6 91%

Reaction Conditions:

with trichlorophosphate at 110;

References:

Knight, Roland L.;Allen, Daniel R.;Birch, Helen L.;Chapman, Gayle A.;Galvin, Frances C.;Jopling, Louise A.;Lock, Christopher J.;Meissner, Johannes W.G.;Owen, David A.;Raphy, Gilles;Watson, Robert J.;Williams, Sophie C. [Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,# 2,p. 629 - 633]

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