2-Chloro-9-(tetrahydropyran-2-yl)adenine synthesis

8synthesis methods

Product Name:2-Chloro-9-(tetrahydropyran-2-yl)adenine
CAS Number:77111-77-4
Molecular formula:C10H12ClN5O
Molecular Weight:253.69

2,6-Dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

20419-68-5
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2-Chloro-9-(tetrahydropyran-2-yl)adenine

77111-77-4
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Yield:77111-77-4 96%

Reaction Conditions:

with ammonia in methanol at 80; for 15 h;Sealed tube;

Steps:

187.2 Step 2:

A mixture of 2,6-dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine (300 mg, 1.10 mmol, 1.0 eq) and ammonia in methanol (5 mL, 7 mol/L, 32.0 eq) in a sealed tube was stirred at 80 °C for 15 hours. The reaction mixture was evaporated to dryness in vacuum. The residue was concentrated to give 2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (270 mg, 96% yield) as a white solid.

References:

WO2020/186220,2020,A1 Location in patent:Paragraph 0376

110-87-2 Synthesis