![](/CAS/GIF/77111-77-4.gif)
2-Chloro-9-(tetrahydropyran-2-yl)adenine synthesis
- Product Name:2-Chloro-9-(tetrahydropyran-2-yl)adenine
- CAS Number:77111-77-4
- Molecular formula:C10H12ClN5O
- Molecular Weight:253.69
![2,6-Dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine](/CAS/GIF/20419-68-5.gif)
20419-68-5
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![2-Chloro-9-(tetrahydropyran-2-yl)adenine](/CAS/GIF/77111-77-4.gif)
77111-77-4
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Yield:77111-77-4 96%
Reaction Conditions:
with ammonia in methanol at 80; for 15 h;Sealed tube;
Steps:
187.2 Step 2:
A mixture of 2,6-dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine (300 mg, 1.10 mmol, 1.0 eq) and ammonia in methanol (5 mL, 7 mol/L, 32.0 eq) in a sealed tube was stirred at 80 °C for 15 hours. The reaction mixture was evaporated to dryness in vacuum. The residue was concentrated to give 2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (270 mg, 96% yield) as a white solid.
References:
WO2020/186220,2020,A1 Location in patent:Paragraph 0376
![3,4-Dihydro-2H-pyran](/CAS/GIF/110-87-2.gif)
110-87-2
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![2-Chloro-9-(tetrahydropyran-2-yl)adenine](/CAS/GIF/77111-77-4.gif)
77111-77-4
33 suppliers
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