2-CHLORO-N-[4-(4-CHLOROPHENOXY)PHENYL]ACETAMIDE synthesis
- Product Name:2-CHLORO-N-[4-(4-CHLOROPHENOXY)PHENYL]ACETAMIDE
- CAS Number:36160-92-6
- Molecular formula:C14H11Cl2NO2
- Molecular Weight:296.15
Yield:36160-92-6 100%
Reaction Conditions:
with triethylamine in dichloromethane at 20;Inert atmosphere;
Steps:
2-chloro-N-(4-(4-chlorophenoxy)phenyl)acetamide(1b)
General procedure: In a dichloromethanesolution (2-3 mL) of chloroacetylchloride (1.1 eq), adichloromethane solution (8-10 mL) of the appropriate amine (1 eq) andtriethylamine (1.1 eq) was added dropwise and the reaction mixture was stirredovernight at room temperature under a nitrogen atmosphere. The reaction mixturewas evaporated and the residue was extracted with ethyl acetate-brine. Theorganic layer was dried over Na2SO4 and upon rotary evaporationgave the desired product, which was pure in most cases (by TLC). In certaincases, chromatography was applied for further purification
References:
Papadopoulou, Maria V.;Bloomer, William D.;Rosenzweig, Howard S.;O'Shea, Ivan P.;Wilkinson, Shane R.;Kaiser, Marcel;Chatelain, Eric;Ioset, Jean-Robert [Bioorganic and Medicinal Chemistry,2015,vol. 23,# 19,art. no. 12518,p. 6467 - 6476] Location in patent:supporting information