![](/CAS/GIF/50772-53-7.gif)
2-CHLORO-N-(4-METHYL-1,3-THIAZOL-2-YL)ACETAMIDE synthesis
- Product Name:2-CHLORO-N-(4-METHYL-1,3-THIAZOL-2-YL)ACETAMIDE
- CAS Number:50772-53-7
- Molecular formula:C6H7ClN2OS
- Molecular Weight:190.65
![2-Amino-4-methylthiazole](/CAS/GIF/1603-91-4.gif)
1603-91-4
285 suppliers
$5.00/1g
![Chloroacetyl chloride](/CAS/GIF/79-04-9.gif)
79-04-9
352 suppliers
$12.00/5g
![2-CHLORO-N-(4-METHYL-1,3-THIAZOL-2-YL)ACETAMIDE](/CAS/GIF/50772-53-7.gif)
50772-53-7
19 suppliers
$60.00/500mg
Yield:50772-53-7 92%
Reaction Conditions:
with triethylamine in dichloromethane at 20; for 1 h;Cooling with ice;
Steps:
1
EXAMPLE 1Preparation of 2-(2-chloroacetyl)amino-4-methylthiazole (III-1)1.14 g of compound II-1 (10 mmol), 1.31 g of dry triethylamine (13 mmol) and 50 mL of dry CH2Cl2 are added into a 100 mL of round-bottom flask to form a mixture. The mixture is cooled with an ice-water bath under stirring. Then 1.24 g of the solution of chloroacetyl chloride (11 mmol) dissolved in 5 mL of dry CH2Cl2 is added dropwise slowly, after completion, the reaction mixture is stirred for 1 hour under the room temperature. The reaction mixture is diluted with 50 mL of CH2Cl2, followed by washed with the saturated saline. The organic phase is dried by anhydrous Na2SO4, and then the solvent is removed on the rotary evaporator. The resulting residue is purified by column chromatography to obtain the pure product of compound III-1, 1.75 g, and the yield is 92%. The product is a colorless crystal, and the melting point is 128-129° C., and the peak values of IR (KBr) are 3185, 3053, 1653, 1578 and 1380 cm-1. The compounds of II-1 and III-1 are one of the compounds having general formula II and III, respectively.
References:
US2011/281922,2011,A1 Location in patent:Page/Page column 3