2-CHLORO-N-(5-FLUORO-2-METHYLPHENYL)ACETAMIDE synthesis

Yield:85817-59-0 100%

Reaction Conditions:

in tetrahydrofuran at 20; for 20 h;

Steps:

338.1 Step 1. 2-Chloro-N-(5-fluoro-2-methylphenyl) acetamide

Step 1.
2-Chloro-N-(5-fluoro-2-methylphenyl) acetamide
A solution of 2-methyl-5-fluoroaniline (0.880 g, 7.03 mmol) and chloroacetyl chloride (1.12 mL, 14.1 mmol) in THF (10 mL) was stirred at room temperature for 20 h.
The solvent was concentrated and dried under high vacuum to give 2-chloro-N-(5-fluoro-2-methylphenyl)acetamide (1.46 g, 100%) as a gray solid. 1H NMR (CDCl₃, 400 MHz) δ 8.30 (br s, 1H), 7.86 (dd, 1H), 7.14 (dd, 1H), 6.81 (td, 1H), 4.24 (s, 2H), 2.27 (s, 3H); LC-MS (ESI) m/z 224.0 [M+Na]⁺.

References:

US2017/253569,2017,A1 Location in patent:Paragraph 0919-0920