2-CHLORO-N-HYDROXY-ISONICOTINAMIDINE synthesis

Yield:-

Reaction Conditions:

with hydroxylamine hydrochloride;sodium carbonate in ethanol;water at 80; for 18 h;

Steps:

2

Preparation 2: 2-Chloro-N-hydroxyisonicotinamidine A solution of sodium carbonate (382mg, 3. 61mmol) and ammonium hydroxide hydrochloride salt (502mg, 7. 22mmol) in water (10ml) was added to 2-chloro-4-cyanopyridine (l. Og, 7. 22mmol) and the mixture heated to 80°C. Sufficient ethanol (10ml) was then added to give a homogeneous solution. After 18h, the solution was cooled and the ethanol removed in vacuo. The solid precipitate was collected by filtration, washed with ethanol and CH2Cl2then dried, affording the title compound: RT = 0.86min ; mlz (ES+) = 172.1 [M+H] +.

References:

WO2005/61489,2005,A1 Location in patent:Page/Page column 24