(2-Chloro-pyridin-3-yl)-acetic acid methyl ester synthesis
- Product Name:(2-Chloro-pyridin-3-yl)-acetic acid methyl ester
- CAS Number:123222-09-3
- Molecular formula:C8H8ClNO2
- Molecular Weight:185.61
67-56-1
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Yield:123222-09-3 100%
Reaction Conditions:
with acetyl chloride at 70; for 18 h;
Steps:
13
INTERMEDIATE 13; r2-Chloropyridin-3-yl)acetic acid methyl ester; To a suspension of Intermediate 12 (3.88 g, 22.6 mmol) in methanol was added acetyl chloride (1.8 mL, 24.9 mmol) and the mixture heated at 700C for 18 hours. The solvents were removed in vacuo to give the title compound as a pale brown oil (4.63 g, quant). δH (DMSOd6) 8.35 (IH, dd, J4.7, 1.9 Hz), 7.88 (IH, dd, J 8.5, 1.9 Hz), 7.43 (IH, dd, J8.5, 4.7 Hz), 3.80 (2H, s), 3.65 (3H, s). LCMS (ES+) RT 2.40 minutes, 186 (M+H)+.
References:
WO2007/88345,2007,A1 Location in patent:Page/Page column 24
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