ChemicalBook CAS DataBase List 2-Chloromethyl-3,4-dimethoxypyridinium chloride

2-Chloromethyl-3,4-dimethoxypyridinium chloride synthesis

12synthesis methods

Product Name:2-Chloromethyl-3,4-dimethoxypyridinium chloride
CAS Number:72830-09-2
Molecular formula:C8H11Cl2NO2
Molecular Weight:224.08

72830-08-1
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$15.00/1g

2-Chloromethyl-3,4-dimethoxypyridinium chloride

72830-09-2
451 suppliers
$15.19/1g

Yield:72830-09-2 98%

Reaction Conditions:

with bis(trichloromethyl) carbonate;Triphenylphosphine oxide in toluene at 20 - 60; for 4 h;

Steps:

9
Ph3PO (43.78 g, 157.5 mmol) was dissolved in toluene (100 mL) in a 500 mL three-necked flask and BTC(14.84 g, 50 mmol) was dissolved in toluene (60 mL) and placed in a 150 mL constant pressure dropping funnel. BTC was added dropwise at room temperature and the temperature was raised to 60 ° C after completion of the dropwise addition.After 2 hours of incubation, 2-hydroxymethyl-3,4-dimethoxypyridine (25.35 g, 150 mmol) was dissolved in 75 mL of toluene and added at 40 ° C to precipitate a white solid. After incubation for 2 hours, The reaction was stopped and the white solid was obtained by suction filtration and dried to give 32.78 g of 2-chloromethyl-3,4-dimethoxypyridine hydrochloride, the product yield was 98%

References:

Zhejiang University of Technology;Hainan Weikang Pharmaceutical (Qianshan) Co., Ltd.;Weng Yiyi;Su Weike;Wang Jincan;Wang Ningqing;Zhong Da;Zhu Zhixin CN107011252, 2017, A Location in patent:Paragraph 0079; 0080

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72830-07-0 Synthesis