2-CHLOROMETHYL-4-METHYL-THIAZOLE synthesis
- Product Name:2-CHLOROMETHYL-4-METHYL-THIAZOLE
- CAS Number:50398-72-6
- Molecular formula:C5H6ClNS
- Molecular Weight:147.63
13750-63-5
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$46.00/100mg
50398-72-6
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$65.00/100mg
Yield:50398-72-6 88.3%
Reaction Conditions:
with thionyl chloride in dichloromethane at 0 - 20; for 1 h;
Steps:
1.2 Step 2: Preparation of 2-(chloromethyl)-4-meth lthiazole (3)
To a stirred solution (4-methylthiazol-2-yl)methanol (2, 1 g, 7.7 mmol) in DCM (20 mL), was added SOCl2(0.89 mL, 11.55 mmol) drop wise at 0 °C and the reaction mixture was stirred at rt for 1 h (Reaction condition b). The reaction mixture was evaporated under vacuum and dried to afford the product as brown oil (3) (1 g, 88.3 %, Yield). NMR (400 MHz, CDC13) δ (ppm): 6.91 (s, 1H), 4.82 (s, 2H), 2.45 (s, 3H).
References:
WO2019/77631,2019,A1 Location in patent:Paragraph 000133; 000331
13750-68-0
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50398-72-6
23 suppliers
$65.00/100mg